The company is inviting nonprofits such as non-government organizations to participate in this trial if they have the logistics to participate in observational trials and to distribute the Artemisinin in their home countries. The trial is expected to accrue a minimum of 3,000 patients. At present the company is engaged in
This study is designed to evaluate the safety, tolerability, and effectiveness of Artemisinin when used in combination with standard of care (SoC) in mild and moderate COVID-19 patients. Artemisinin is an anti-viral agent with demonstrated activity against SARS-CoV-2 in-vitro comparable to remdesivir, however, with higher safety index. By targeting the host protein, TGF-β, Artemisinin avoids resistance mutations which could render vaccine and/or therapeutics against viral protein(s) ineffective.
Artemisinin can target multiple viral threats including COVID-19 by suppressing both viral replication and clinical symptoms that arise from viral infection. Viral replication cannot occur without TGF-β. Artemisinin, purified from a plant Artemisia annua, is able to inhibit TGF-β activity and is able to neutralize SARS-CoV-2 (COVID-19) in vitro at an EC50 of 0.45 ug/ml (Mateon’s test result at
Mateon was created by the recent reverse merger with Oncotelic which became a wholly owned subsidiary of
About Abiogenesis Clinpharm
Abiogenesis Clinpharm Private Limited (Abiogenesis) is
Initiated by a vibrant group of experienced professionals in the clinical trial domain with proven track record, Abiogenesis has committed to exceeding the needs and expectations of its clients by providing an innovative, professional and high quality services with integrity and reliability. Abiogenesis is capable of delivering the quality work from early proof of concept studies to late phase clinical development including post launch product lifecycle management. We believe that each therapeutic product should go through evaluation in clinical development program with all compliances and this is possible when the organizational value system ensures individual integrity, transparency, respect, productivity and compassion. With an execution level experience in most of
Mateon's Cautionary Note on Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical facts, included in this communication regarding strategy, future operations, future financial position, prospects, plans and objectives of management are forward-looking statements. Words such as “may”, “expect”, “anticipate” “hope”, “vision”, “optimism”, “design”, “exciting”, “innovative”, “promising”, “will”, “conviction”, "estimate," "intend," "believe", “quest for a cure of cancer”, “innovation-driven”, “paradigm-shift”, “high scientific merit”, “impact potential” and similar expressions are intended to identify forward-looking statements. Forward-looking statements contained in this press release include, but are not limited to, statements about future plans, the progress, timing, clinical development, scope and success of future clinical trials, the reporting of clinical data for the company’s product candidates and the potential use of the company’s product candidates to treat various cancer indications. Each of these forward-looking statements involves risks and uncertainties and actual results may differ materially from these forward-looking statements. Many factors may cause differences between current expectations and actual results, including unexpected safety or efficacy data observed during preclinical or clinical studies, clinical trial site activation or enrollment rates that are lower than expected, changes in expected or existing competition, changes in the regulatory environment, failure of collaborators to support or advance collaborations or product candidates and unexpected litigation or other disputes. These risks are not exhaustive, the company faces known and unknown risks, including the risk factors described in the company’s annual report on Form 10-K filed with the
Source: Mateon Therapeutics, Inc.